One of the most difficult problems when nanomedicine is used in the treatment of malignant tumors is that the tumor targeting efficiency is low, and it is difficult for the released drugs to specifically kill tumor cells. Tumor targeting efficiency has become a bottleneck in the development and clinical application of nanomedicine.
In response to the problem of poor tumor targeting of nanomaterials, the Institute of Physics and Chemistry Technology, Chinese Academy of Sciences, under the leadership of Researcher Tang Fangqiong, has been committed to developing new nanocarriers and their biomedical applications in recent years. In 2009, they published a new method for the synthesis of sandwich silica with a hollow mesoporous structure (Adv. Mater. 2009, 21, 3804-3807), and then did a series of work on the biomedical application of sandwich silica Related articles were published in Angew Chem. Int. Ed., ACS Nano, Biomaterials.
Recently, they have teamed up with Xuanwu Hospital of Capital Medical University, Sun Yixian Cardiovascular Hospital of Shenzhen City, Academy of Military Medical Sciences, Beijing Huamei Jingchuang Nanophase Material Technology Co., Ltd. and many other units to design a new and efficient tumor targeting strategy: The drug-loaded sandwich silica nanoparticles are bound to mesenchymal stem cells. The mesenchymal stem cells are attracted by the cytokines secreted by the tumor cells and can actively track the tumor cells, and deliver the drug-loaded nanoparticles to various parts of the tumor tissue for release Drugs cause tumor cell apoptosis. This new targeting method uses chemotaxis-derived mesenchymal stem cells as a "targeted transport vehicle". Like the "Trojan horse", the inside and outside should completely kill the tumor cells, which is more powerful than the traditional targeting method. Proactive, targeted and targeted.
The research results have opened up new ideas for tumor targeting methods of nanomedicine, and brought new hope for improving the clinical application of nanomedicine. The reviewers believe that "they use innovative and interesting nanomaterials, combined with mesenchymal stem cells, so that drug-loaded nanoparticles can efficiently target and kill tumor cells like bullets."
The research results were recently published online in ACS Nano. The research was strongly supported by the "863" project of the Ministry of Science and Technology and the National Natural Science Foundation of China.
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