As many as 15% of couples worldwide are affected by infertility. In vitro fertilization (IVF) is a treatment for this common disease. In a new study published in the December 19 issue of Cell, researchers at Peking University reported a safe, accurate, and inexpensive method for selecting genetically normal embryos for IVF procedures, thus improving The opportunity for a couple to have healthy children.
By sequencing the entire genome of a single egg cell, this method can detect chromosomal abnormalities and DNA sequence variations associated with genetic diseases. The author of the paper, Professor Jie Qiao of Peking University Third Hospital said: "With this method, we can kill two birds with one stone: using a set of deep sequencing analysis to avoid two genetic problems. In theory, if this method Being able to work well, we will be able to increase the success rate of IVF technology from 30% to 60% or even higher. "
The IVF procedure involves removing the female egg and male sperm and placing it in an experimental dish to fertilize it. The embryo precursor, the fertilized egg, is transplanted back into the mother's womb to develop into a fetus. There are currently various procedures that can be used to detect genetic defects in preimplantation embryos, but these methods are often invasive and require some cells from growing embryos, and cannot simultaneously detect chromosomal abnormalities and DNA sequence variations related to genetic diseases .
Researchers have recently developed some whole-genome sequencing methods that can simultaneously detect two defects in a single human sperm cell, but until now, no similar method has been applied to egg cells, and chromosomal abnormalities in egg cells are compared to sperm cells. More common.
In this new study, Professor Suney Xie who worked at Peking University and Harvard University, together with Professor Qiao Jie of Peking University and Researcher Fucho Tang, developed a sequencing polar body Whole genome approach. In the process of female germ cell formation, it undergoes two multiplier divisions to form a large haploid egg cell and 2-3 small cells. These small cells are called polar bodies. Since polar bodies are optional for human embryo development, they can be safely removed without damaging the embryo.
Xie Xiaoliang said: "We are initiating a clinical trial based on this method. If the clinical trial works, this technique may greatly improve the success rate of in vitro fertilization, especially for those older and habitual abortion Women. "
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