Normal cells have a limited number of divisions. Therefore, cells obtained from normal tissues will die after a certain number of divisions. This phenomenon is called cell senescence. It is now believed that senescence is due to the DNA terminal sequence of telomeres in each The secondary cell division cannot be replicated normally and is gradually shortened. As a result, the telomere is continuously shortened as the number of cell divisions increases, and eventually the cell can no longer divide [Bodnet et al., 1998]. However, the germ cells This is not the case with transformed cells.These cells often extend the lifespan of cells by expressing telomerase that can replicate telomere DNA, and even make germ cells and some tumor cells have unlimited proliferation capacity.
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