The basis for the continuation of life is inheritance, and the DNA sequence information of the parents will be passed on to the children. Every cell in an organism has the same DNA sequence, so what determines their development into different tissues and organs?
"Research in recent years has found that this is determined by epigenetic information. It allows animals to differentiate from a fertilized egg into more than 200 cells of different phenotypes on the basis of only one set of DNA sequences, which eventually forms the brain, "Different organs such as the heart." Liu Jiang said, "But whether epigenetic information can be passed from parents to offspring and how it is transmitted has been an unsolved mystery."
Liu Jiang ’s team used zebrafish with a similarity to human genes as high as 85% as a model and found that in addition to the DNA that can be passed from parents to offspring during zebrafish embryo development, the DNA methylation profile of sperm can also be inherited. In the offspring, and used to guide early embryo development. The methylation of DNA is the most important type of epigenetic information.
The results of this study subvert the traditional belief that early embryonic development is mainly determined by the egg, proving that the offspring inherits the DNA methylation profile of the paternal source, discards the maternal profile, and the information carried in the sperm guides the development of the embryo.
Relevant experts said that the study proved that in addition to DNA sequences, DNA methylation patterns can also be inherited. This result fills the gap of epigenetic information genetic theory, will provide a theoretical basis for the development and application of stem cells and their translational medicine, and also provide new ideas for the treatment of some diseases, and also help to improve cloning, in vitro fertilization and reproduction technology. And application.
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