New mechanism of AIDS immunity may be used to develop AIDS vaccine
The mortality rate of AIDS is extremely high, and the social harm is great. Its prevention and treatment has been a major topic of general concern in the medical community in recent years. According to British media reports on September 19, researchers from the United States and Europe have recently discovered a new way of treating AIDS, which can effectively prevent HIV from damaging the body's immune system.
When a person is infected with HIV, the body will immediately take defensive measures. But researchers have found that HIV can induce the body to take too strong a response, which ultimately leads to damage to the body's immune system and weakens the body's adaptive immune function. In the words of Adriano Boazo, a professor at Imperial College London who is in charge of the project, this is like "the gear will burn out when you drive in a gear for too long."
The researchers found that HIV enters the body and takes away the cell membrane of the infected cells, relying on the cholesterol in the cell membrane to maintain fluidity, and triggers the "plasma-like dendritic cells (pDC)" in the infected person, while releasing interferon . Interferon can activate a series of immune responses in the body. These immune reactions will not have adverse effects in a short time, but will damage the human immune system after a long time.
Based on this working principle of HIV, the researchers cleared the cholesterol in their cell membranes, so that the body can adapt to the immune function and operate normally, thereby strengthening the body's immune ability.
Professor Boaso believes that this is like turning HIV into a "flaunted but unarmed force, so that other troops can easily find and eliminate it." Currently, Boazo's team is studying the feasibility of applying this principle to develop a new AIDS vaccine.
The spread of AIDS is diverse, so prevention and control are very difficult. Every year, 1.8 million people worldwide die from AIDS. In 2009 alone, about 2.6 million people were infected with AIDS, and 3.33 million people were HIV carriers. All parties, including enterprises, governments and civil organizations, are actively looking for ways to overcome HIV, but so far progress has been very limited. In a 2009 study conducted in Thailand, the efficacy of the AIDS vaccine was first confirmed, but the effective rate reached only 30%.
In May this year, an American research team announced that they used a variant of HIV to help an HIV-infected monkey successfully control the disease for a year, and hoped to develop a practical and effective vaccine for human AIDS. .
This latest discovery was published in the journal Blood on September 19.
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