A recent study from the Fourth Affiliated Hospital of Harbin Medical University proved that fruit raspberry can significantly inhibit the proliferation of liver cancer cell lines, reduce the expression of vascular endothelial growth factor (VEGF) in liver cancer cells, and increase the expression of wild-type tumor suppressor gene p53. For the first time in the research, the researchers successfully locked the two specific protein targets of raspberry to prevent the growth of liver cancer cells, which provided an important theoretical basis for the prevention of primary liver cancer by fruits and vegetables.
Raspberries are also called raspberries, trays, and raspberries. They are perennial deciduous shrubs of the Rosaceae family. There are more than 750 species. Their fruit type, color, and taste are similar to strawberries, but they grow on trees, so they are named raspberries. This fruit contains a large amount of vitamin C, E, superoxide dismutase, Y-aminobutyric acid and other anti-aging substances, as well as anti-cancer substances such as tannin. Among them, the content of vitamin E and tannin is the most of all fruits. In the United States, red raspberry is regarded as a cancer nemesis, and people praise it as "Ruby".
During his training at Cornell University in 2000, Dr. Liu Ming from the Fourth Academy of Harbin Medical University tried to culture the tannin in raspberries and liver cancer cells, and found that the former can significantly inhibit the growth of the latter. After returning to China, he has focused his research on the medicinal value of natural plants. He has found that grapes and apples can prevent cancer cell proliferation. With the support of the National Natural Science Foundation of China and the Heilongjiang Science and Technology Research Project, he led the research team to further develop the "Raspberry Prevention and Inhibition Mechanism of Liver Cancer" from the perspectives of medicine, nutrition, botany, cytology, molecular biology, etc. Research".
The results show that as the concentration of phytochemicals in raspberries increases, the total antioxidant free radical scavenging ability also increases. The inhibition rate of the raspberry extract from 0.25 mg / ml to 10 mg / ml on the liver cancer cell line HepG-2 showed a gradual increase trend, with the highest inhibition rate reaching about 90%. The results of polymerase chain reaction showed that raspberry extract had a strong ability to inhibit the expression of VEGF and affect the expression of wild p53 in vitro. As the concentration of raspberry extract increased, the expression of VEGF decreased and the expression of wild p53 increased.
In the stable rat primary liver cancer model established by the chemical poisons aflatoxin and diethylnitrosamine, as the concentration of raspberry extract increased, the tumor diameter on the liver of the experimental group became smaller and the number of tumors The rate of tumor formation was reduced, and the degree of nodules was reduced. The expression levels of VEGF and proliferating cell nuclear antigen in liver cancer cells were also significantly reduced. At the same time, the serum of rats in the experimental group was significantly different from that of the raspberry intervention group and normal rats on the two specific protein (M2597, M4513) qualitative peaks, indicating that the protein peaks M2597 and M4513 are likely to be the protein role of raspberry in preventing liver cancer. Target.
Expert evaluation pointed out that at present, there are two synergistic risk factors that greatly increase the risk of liver cancer, one is chronic hepatitis B virus infection, and the other is the highly toxic liver toxin produced by mold contaminating the staple food-Aspergillus flavus Chronic exposure of toxins. One of the important ways to reduce the impact of these two carcinogenic factors is chemoprevention, which is to offset the harm of aflatoxin by taking drugs or food supplements. In the future, the use of phytochemicals extracted from raspberries, proper combination and composition of preventive agents will help prevent the occurrence of liver cancer, and can inhibit the development of liver cancer and improve the survival rate of patients with this disease.
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