Scientists use X-rays to take pictures of cells without damage
Carolyn Larabell of Lawrence Berkeley National Laboratory in California, USA, and colleagues reported at the annual meeting of the American Association for the Advancement of Science in Vancouver, Canada, that they successfully captured an internal image of a complete cell using X-rays.
Just like a CT scan of a cell, the researchers first quickly frozen a cell and imaged it every 100 milliseconds.
They were then able to reconstruct the entire cell with 90 to 200 images in 5 minutes. Using organelles, the functional structure of cells, and different light absorption characteristics, scientists can automatically identify and color-code this internal mechanism, just like the T cells shown in the figure.
Researchers can use this new technology to count and calculate the volume of organelles, and even measure how much hemoglobin the Plasmodium consumes in new red blood cells.
The researchers point out that prying into the interior of a complete cell without laborious slicing and coloring with an electron microscope makes X-ray imaging faster, more quantitative, and obviously not messed up
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