The edge of the epithelial cell layer will automatically expand to the blank space

The discovery of this basic cell pattern will help scientists better understand cell movement during processes such as tumor invasion, embryonic development, and wound healing.

A single layer of epithelial cells is only one layer thick and is commonly found in body cavities and body surfaces, such as skin, lungs, and blood vessels. Jeffrey Fredberg et al. Used a single-layer stress microscope to detect the moving speed, cell traction force and intercellular stress of the epithelial cell layer, and pasted a circular area where the cells could not adhere.

They found that the cells near the non-adherent area used traction on the substrate to allow the epithelial cell layer to expand toward the unfilled area, regardless of whether the cells were moving closer, farther away, or unrelatedly at the edges.

Although the researchers have not yet clarified the mechanism behind this, they believe that this effect on cell layer movement is ubiquitous and should be used to improve the design of the tissue skeleton in regenerative medicine.

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