Although various compounds are currently being developed to combat cancer, they all have serious side effects. In addition, tumors can develop resistance to these compounds.
To counteract these two shortcomings, the scientists designed a new peptide-based therapy that uses peptides from the wasp venom as a potential new way to prevent breast cancer.
This peptide has the ability to form pores in the plasma membrane of the cell and penetrate into cancer cells, or induce cancer cell necrosis or trigger apoptosis, which ultimately leads to cancer cell death.
However, this powerful "natural weapon" is currently not available for treatment because of its high toxicity and lack of cell specificity, which not only damages tumor cells, but also affects healthy cells of patients. Therefore, researchers have devised a means to deliver peptides to tumors in a specific and controlled manner and to accumulate them in tumor cells.
The system consists of a carrier polymer loaded with two "components": a peptide that binds to the tumor cell receptor and a toxic peptide of the wasp venom. In vitro experiments have shown that the toxic peptides of the wasp venom are adequately delivered and distributed in tumor cells and cause their death, while normal cells such as red blood cells are not affected.
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