Separation and preparation of a compound isomer

Isomers of a compound have strong anesthesia from deep to shallow, clinically proven that local anesthesia is equivalent to cocaine; nerve conduction block is 5.25 times that of cocaine and 13 times that of procaine; infiltration anesthesia The effect is much stronger than procaine and cocaine. The sample composition is complex, containing many impurities that are difficult to separate, and the content is about 21%. In order to obtain the target product with a content of more than 99%, and at the same time save costs, first of all, a large number of samples are injected with resin fillers for rough separation, and then the collected liquid containing the substance obtained by the rough separation is evaporated to dryness and then re-used with a resin column Separate. Through two preparations and separations, the target compound content in the product is 99.5%, and the yield is high and the cost is low.

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